Welcome to the Journal of Prolotherapy

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Featured Article


April 1, 2012

Stabilization of Rheumatoid Thumb Interphalangeal Joint Boutonniere Deformity and Severe Subluxation with Splinting and Prolotherapy: A Case Report

Case Reports, Ross A. Hauser, MD, Shelby Ostergaard, Susan Santilli, OTR/L, CLT, Volume 4 : 2012

In this clinical case, a 57-year-old white female afflicted with rheumatoid arthritis received treatment for a 35-degree interphalangeal (IP) thumb joint deviation. The thumb deviation clinically described as a boutonniere (French for buttonhole) deformity was treated with a combination of Prolotherapy and splinting. She wore a custom three-point splint for six weeks and received three separate Prolotherapy treatments within that six-week period. After treatment, the deviation decreased from 35 degrees to 10 degrees, and her thumb pain decreased from 7 to 1 on a pain scale of 10 as the highest level.

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Featured Article


April 1, 2012

Understanding Adipose-derived Stromal Vascular Fraction (AD-SVF) Cell Biology and Use on the Basis of Cellular, Chemical, Structural and Paracrine Components: A Concise Review

Robert W. Alexander, MD, DMD, FICS, Volume 4 : 2012

In the past 10 years, biocellular regenerative medicine has recognized the potential value and availability of a heterogeneous, undifferentiated, nucleated cell population with the adipose tissue complex (ATC). With the recognition of higher mesenchymal stem cell concentrations, ease and safety of access, and the very heterogeneous undifferentiated cell populations in the native 3D adipose matrix, many researchers and clinicians are moving from bone marrow sources to the adipose complex.

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Welcome to the Journal of Prolotherapy®


The Journal of Prolotherapy® is a peer-reviewed journal with the purpose of providing the readers with new, cutting-edge information on Prolotherapy, as well as provide a forum for physicians and patients alike to tell their stories.

As of 2012, all issues of the Journal of Prolotherapy are FREE to access online.

Why the Journal of Prolotherapy®?


Our mission is to educate the world about the life-changing effects of Prolotherapy. Like you, we want more people to know that there is hope to get out of chronic pain and that hope is Prolotherapy.

When a person finds out about Prolotherapy for the first time, they often say or think “why haven’t I heard of this before?” JOP is doing their best to make sure everyone in chronic pain has at least heard about Prolotherapy. The skeptics of Prolotherapy often say that research is lacking. To put more of it out there, we continue to print in electronic and paper journal format, the experiences of doctors and patients with Prolotherapy. The whole journal revolves around the regenerative injection technique known as Prolotherapy.

JOP believes that it is important to get both the doctors’ and the patients’ perspectives. We believe that the greatest evidence for the effectiveness of Prolotherapy is not going to come from a “double-blind scientific study” but from the millions of changed lives from Prolotherapy. In essence, almost every patient that gets Prolotherapy proves that Prolotherapy works.

Most folks who get Prolotherapy have a chronic degenerative condition. These conditions are supposed to get worse with time. When such a person receives Prolotherapy and their condition subsequently reverses, as evidenced not only by the relief of pain, improvement in activity level, decrease in medication usage and usage of other health care for their pain, but also by X-ray and MRI improvement, this, in our opinion, is definitive proof that Prolotherapy does, indeed, regenerate structures.

With your help, we hope to continue to change lives. We want to get people back to sports, back to being active and without pain, back to being the kind of people they wish to be! We see hundreds, thousands, even millions of people getting out of pain because they received the life-changing effects of Prolotherapy. We believe that this is a cause worth fighting for! We hope you will join the fight by subscribing to JOP, writing articles, case studies, even your own experience with Prolotherapy, and get others on this crusade. Together educating the world about a successful treatment for chronic pain…and that treatment is Prolotherapy!

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