Ross Hauser, MD writes an extensive review of the effects of NSAIDs on articular cartilage. He reveals that in both in vitro and in vivo studies in both animals and humans it is clear that NSAIDs have been shown to have a significantly negative effect on cartilage matrix which causes an acceleration of the deterioration of articular cartilage in osteoarthritic joints. The preponderance of evidence shows that NSAIDs have no beneficial effect on articular cartilage in OA and actually accelerate the very disease for which they are most often used and prescribed. For the full article, get a copy of JOP 2:1.
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